Significant reductions in infection risk were seen starting at 12 days after the first dose, reaching 60% (95% CI 49–68) for ChAdOx1 nCoV-19 and 69% (66–72) for BNT162b2 at 21–44 days and 72% (63–79) for BNT162b2 after 45–59 days. 3106 of 103 622 vaccinated individuals and 50 340 of 464 356 unvaccinated controls tested positive for SARS-CoV-2 infection. Local effects were similarly higher in individuals previously infected than in those without known past infection (1♴ times after the first dose of ChAdOx1 nCoV-19 and 1♲ times after the first dose of BNT162b2). Systemic side-effects were more common (1♶ times after the first dose of ChAdOx1 nCoV-19 and 2♹ times after the first dose of BNT162b2) among individuals with previous SARS-CoV-2 infection than among those without known past infection. Local side-effects were reported by 71♹% (150 023 of 208 767) of individuals after the first dose of BNT162b2, by 68♵% (9025 of 13 179) after the second dose of BNT162b2, and by 58♷% (104 282 of 177 655) after the first dose of ChAdOx1 nCoV-19. Systemic side-effects were reported by 13♵% (38 155 of 282 103) of individuals after the first dose of BNT162b2, by 22♰% (6216 of 28 207) after the second dose of BNT162b2, and by 33♷% (116 473 of 345 280) after the first dose of ChAdOx1 nCoV-19. Learn more about VICP.Between Dec 8, and March 10, 2021, 627 383 individuals reported being vaccinated with 655 590 doses: 282 103 received one dose of BNT162b2, of whom 28 207 received a second dose, and 345 280 received one dose of ChAdOx1 nCoV-19. In the very rare event that a vaccine causes a serious problem, the National Vaccine Injury Compensation Program (VICP) may offer financial help to individuals who file a petition. You or your doctor can choose to report the side effect to the Vaccine Adverse Event Reporting System (VAERS). Talk with your doctor if you’re concerned about your health after getting vaccinated. The Countermeasure Injury Compensation Program (CICP) may help pay for the costs of medical care and other expenses for people seriously injured from a COVID-19 vaccine. If you experience a severe allergic reaction, call 9-1-1, or go to the nearest hospital. What if I feel sick after getting vaccinated? Keep in mind that getting vaccinated is much safer than getting the diseases vaccines prevent. Centers for Disease Control and Prevention and the Food and Drug Administration to ensure that all recommended vaccines remain safe. Please report any potential side effects experienced from vaccination to the Vaccine Adverse Event Reporting System, a program co-managed by the U.S. Call your vaccination provider or your healthcare provider if you have any side effects that bother you or do not go away. Signs of a severe allergic reaction can include: For example, if 1 million doses of a vaccine are given, 1 to 2 people may have a severe allergic reaction. Serious side effects from vaccines are extremely rare. Learn more about how vaccines provide immunity. Keep in mind that most common side effects are a sign that your body is starting to build immunity (protection) against a disease.
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